SANÀ Guide
Reconstitution, explained clearly.
Understand the information you need before preparing a lyophilised product, and keep every unit and calculation traceable.
A step-by-step overview
Step 1
Check the product documentation
Every figure you will use — the amount in the vial, the diluent and the volume — comes from the documentation supplied with your product.
Step 2
Prepare carefully
Work on a clean, cleared surface with only the items that documentation lists, and follow its instructions for that specific product.
Step 3
Record the final solution details
Write down the total amount, the final solution volume, the resulting concentration and the date, so the solution stays traceable.
Dose calculator
Choose your product and dose to see how much water to add, where to fill the syringe and how long the vial lasts.
1Product
This is a tentative guide to understand how each product works. Your final protocol is defined by our doctor — book a virtual consultation.
Book a virtual consultationBefore you begin
Reconstitution is the act of dissolving a lyophilised product in the liquid its documentation specifies, so that a known amount is held in a known volume. The arithmetic is simple; the difficulty is making sure each figure you use is the one the product actually states.
This guide explains the principles and keeps the units traceable. It does not recommend an amount, choose a diluent, set a volume or describe administration. Those decisions belong to the product documentation and to a qualified healthcare professional.
What you need
- The product's own documentation, in front of you before you start
- The unopened vial in its packaging
- The diluent named in that documentation, in the container it was supplied in
- A syringe whose graduations let you read the documented volume
- A clean, cleared and dry working surface
- A way to record the final solution details in writing
Quantities and specifications are not listed here, because they differ between products. Use the documentation supplied with yours.
Seven preparation steps
Step 1
Read the label first
Start with the documentation supplied with your product. The label and leaflet are the only source for the amount in the vial, the diluent the manufacturer specifies and the volume it states. Nothing on this page replaces that information.
If the documentation is missing or unclear, stop and speak to a qualified healthcare professional.
Step 2
Inspect the packaging and vial
Check that the outer packaging is intact and that the vial, its closure and any seal are undamaged. Note anything that looks unexpected. Appearance alone never establishes that a vial is suitable to use.
A vial cannot be declared safe on the basis of how it looks.
Step 3
Prepare a clean working area
Clear a flat surface, remove anything you do not need and lay out only the items listed in the product documentation. Wash your hands and let the area dry before you open anything.
Step 4
Prepare the vial access points
Remove the protective cap and prepare the closure exactly as the product documentation describes, then allow it to dry fully before access. Handle the diluent container the same way.
Step 5
Measure the documented volume
Draw the volume the documentation states, reading the syringe at eye level against its own graduations. Do not choose a volume yourself, and do not scale it up or down to reach a preferred concentration.
This guide does not select a diluent or a reconstitution volume.
Step 6
Follow the product-specific mixing instructions
Add the liquid in the manner the documentation describes and let the contents dissolve in the way and for the time it specifies. Mixing behaviour differs between products, so follow that product's instructions rather than a general rule.
Step 7
Label, record and store
Write down the total amount in the vial, the final solution volume, the resulting concentration and the date of preparation. Store the prepared vial as the product documentation directs.
Storage conditions and periods vary by product; use the documented conditions for the product in front of you.
Storage and documentation
Storage conditions and periods are product-specific. SANÀ does not publish a single storage period that applies to every prepared solution, and no figure of that kind appears on this page.
What is universal is the record. After preparation, keep a written note of the total amount in the vial, the final solution volume, the resulting concentration, the date of preparation and the storage conditions the documentation specifies. A solution without that record cannot be verified later.
Stop and check
Pause and seek advice from a qualified healthcare professional in any of these situations.
- The documentation does not state a diluent, a volume or a total amount.
- The packaging, vial or closure is damaged, or a seal is missing.
- The contents look different from what the documentation describes.
- Your syringe graduations do not let you read the documented volume.
- You are unsure of any figure you would otherwise have to assume.
Common errors
Confusing the volume added with the final solution volume
The final solution volume is the figure the documentation gives, and it can differ from the amount of liquid you added. Concentration calculations use the documented final volume.
Mixing up milligrams and micrograms
One milligram is one thousand micrograms. Keep the unit written next to every figure you record, including on the vial label.
Reading a syringe scale that is not the one you assumed
Marks on a U-100 scale are not millilitres. Confirm what your syringe is labelled before reading any value from it.
Choosing a reconstitution volume to reach a convenient number
The volume comes from the product documentation, not from the calculation you would prefer to end up with.
Recording nothing after preparation
Without the total amount, the final volume, the concentration and the date written down, the solution cannot be checked later.
Administration scope
This guide stops at the prepared, labelled and recorded solution. It gives no administration instructions, techniques, sites, angles or schedules, and it does not establish that any product is suitable for a given person or purpose.
Anything beyond preparation should be discussed with a qualified healthcare professional, using the documentation supplied with your product.
Frequently asked questions
No. It explains the information you need and where that information comes from. Amounts, diluents and volumes come from the product documentation and from a qualified healthcare professional.
Only the one named in the documentation for your product. This guide does not select a diluent.
There is no single answer that applies to every product. Use the storage conditions and period stated in the documentation for the product you are preparing.
Concentration is the total amount in the vial divided by the final solution volume. The calculator on this page does that for you: choose the product and dose and it shows the water to add and the syringe marking.
No. Every calculation runs in your browser, and no value you enter is transmitted, saved or shared.
Sources and related resources
The authoritative source for any product-specific figure is the documentation supplied with that product, alongside advice from a qualified healthcare professional.
General injection-safety references
These references support the general aseptic and injection-safety principles described here. Product-specific preparation and storage instructions must come from the current documentation supplied with that product.